Showbiz

Joe Manganiello Faces Life-Threatening Health Crisis

Joe Manganiello has revealed a scary health battle which included a life-saving amputation.The 49-year-old actor - whose fiancee Caitlin O'Connor sizzled in a s...

Joe Manganiello Faces Life-Threatening Health Crisis
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Joe Manganiello has revealed a scary health battle which included a life-saving amputation.

The 49-year-old actor - whose fiancee  - has opened up for the first time about suffering from autoimmune-related illnesses in a tough health battle which lasted seven years.

Manganiello is set to release a new memoir - titled Bloodlines -  centered around his previously undisclosed health ordeal.

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According to the press release, the former husband of had been dealing with 'a cascade of autoimmune-related illnesses' which wreaked havoc on his skin, thyroid, eyes, lungs, and digestive system.

This sent him into a seven-year journey which was 'plagued by chronic pain, a life-saving organ amputation, existential crisis, and a prolonged fight for survival that left doctors with few answers and no clear explanation.'

As he was frustrated with traditional medicine's inability to give him any answers, he found a rather unorthodox solution.

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Joe Manganiello (pictured in Austin in March 2025) has revealed a scary seven year health battle which included a life-saving amputation

Manganiello is set to release a new memoir - titled Bloodlines - centered around his previously undisclosed health ordeal

The synopsis explains that the star explored 'shamans, pagan rituals, ancient myths, long-lost family records and the rebirth of his own spirituality.'

On the journey, he looked into his own family genealogy where he discovered ancestors who had survived the Armenian genocide in addition to others who lived with chronic illness. 

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According to the press release, the 49-year-old actor (seen in 2015's Magic Mike XXL) had been dealing with 'a cascade of autoimmune-related illnesses' which reeked havoc on his skin, thyroid, eyes, lungs, and digestive system

Manganiello is engaged to Two and a Half Men actress Caitlin O’Connor as the two are seen together in New York back in December

He and Vergara split in July 2023 after seven years together (pictured in Beverly Hills in March 2022)

The couple announced their engagement in October 2025, revealing Manganiello had actually popped the question months earlier in June.

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He and Vergara split in July 2023 after seven years together.

They said in a statement posted on Instagram at the time: 'We have made the difficult decision to divorce. As two people that love and care for one another very much, we politely ask for respect for our privacy at this time as we navigate this new phase of our lives.'

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