Amy Schumer Hospitalized After Weight Loss Drug Use

has taken to Instagram to show off her slender figure in a see-through gold minidress while at an event this week.

But in her caption the comedienne admitted she had some 'gastro issues' before and during the show.

The Trainwreck star thanked 'the medical staff at Mt Sinai and @atria.health for getting me through the show even though I had some gastro issues leading up to and during the performance I'm proud I made it through. oh boy!'

The 44-year-old movie star has been on the  drug Mounjaro which helped her lost 50lbs while battling Cushing syndrome.

Mounjaro commonly causes gastrointestinal (GI) issues, as it works by to make you feel fuller longer, according to GoodRX.

The most frequent side effects are nausea, vomiting, diarrhea, constipation, and stomach pain.

She has also been on hormone therapy for endometriosis and perimenopause.

After experiencing severe side effects with Ozempic and Wegovy, she later found success with Mounjaro and hormone therapy.

Schumer tried Ozempic and Wegovy but stopped due to severe nausea, noting she couldn't 'handle' the side effects. 

She later transitioned to Mounjaro, which she found more manageable. 

Her weight loss journey was heavily impacted by managing Hashimoto's thyroiditis, according to a February 2026 report from People.com.

In 2025, she started estrogen and progesterone for perimenopause, which helped with energy, skin, and hair, notes a March 2025 report from TODAY.

This month Schumer said she felt 'strong' and 'healthy' after losing the weight.

Besides medication, she has mentioned the impact of previous procedures, such as a liposuction in 2022 following her endometriosis surgery and a laminectomy in 2025 for a back injury, as reported by the New York Post.

Her Wednesday post revealed she was in New York City.

'Nothing like being on stage at @carnegiehall being a part of last night's "letters light and love" was an honor. I read two letters one was about the SS Exodus 1947 a ship that carried 4500 Jewish people after they'd been liberated from the camps,' she wrote. 

'They were denied entry after surviving the annihilation of 6 million Jews and were diverted to prison ships then camps. And the second was from a young woman on her two year to her sister catching up on gossip and celebrating her experience meeting Jews from all over the world. 

'Thank you to everyone who made this night possible. I am proud to be Jewish and to represent my ancestors most of who didn't make it. Loved seeing my sisters @jewdygold @noatishby @juliannamargulies and @therealdebramessing thanks for my dress @luxury_checkins hair @tousledbyjae makeup @apetownes_artistry.' 

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The actress announced in December that she had split from the 45-year-old chef - with whom she has six-year-old son Gene - and as she marked her first Valentine's Day since they went their separate ways, the comedienne poked fun at her situation.

Standing in front of 'crying corner' bunting, she posted on her Instagram Stories: 'Give yourself all the love today. Happy vday (sic).'

Amy confirmed the end of her seven-year marriage to Chris on Instagram following several months of speculation.

Captioning a photo of the former couple riding a train, Schumer - who overlayed the post with U2's track, I Still Haven't Found What I'm Looking For - penned: 'Blah blah blah Chris and I have made the difficult decision to end our marriage after 7 years.

'We love each other very much and will continue to focus on raising our son. We would appreciate people respecting our privacy at this time. (sic)'

The I Feel Pretty star then joked in the caption that her dramatic weight loss and the professional chef being a 'hot James Beard award-winning chef who can still pull some hot tail' were not the causes for their break-up.

She ended the post with: 'Amicable and all love and respect! Family forever.'

The former couple were first linked in November 2017 after they were photographed at a candlelit dinner together in New York.

Just days after they went Instagram official with their relationship in February 2018, the couple got married in an intimate ceremony in Malibu, which was .

Schumer shared a series of photos from their special day to Instagram, and she let the photos speak for themselves by simply captioning the carousel with: 'Yup.'

In October that year, the star made her pregnancy announcement via journalist Jessica Yellin of News Not Noise.

Sharing a list of her recommended congressional and gubernatorial candidates, Yellin wrote: 'I wanted to share some news from our community, maybe it's noise, but it's happy noise.'

And the end of the post stated: 'I'm pregnant-Amy Schumer.'

On May 5, 2019, Gene was born. And referencing the birth of Meghan, Duchess of Sussex, and her husband Prince Harry, Duke of Sussex's son Prince Archie a day later, Schumer